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bmoyernh
This website page on the COVID-19 Pandemic is for educational purposes ONLY
All previous updates are now archived
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Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios, et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A.,
Satyamitra, Merriline M., Tadesse, Yeabsera S., et al.
Source: Radiation Research, 195(1) : 1-24
Published By: Radiation Research Society
bmoyernh
This website page on the COVID-19 Pandemic is for educational purposes ONLY
All previous updates are now archived
~~~~~~~~~~~~~~~
Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios, et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A., Satyamitra, Merriline M., Tadesse, Yeabsera S., et al. Source: Radiation Research, 195(1) : 1-24 Published By: Radiation Research Society
New!
Supplement No. 12
The Origins of SARS-CoV-2
A treatise on the many papers and history of finding the origin of the pandemic;
plus a Supplemental slide on the GOP Senate Minority Report
The June 2023 Update is now FINAL (issued June 1st)
We retain previous months:
The MAY 2023 COVID UPDATE CLICK HEREThere is new data everyday so we provide DRAFTS of our next update to help stay up to date!
We have noticed some links in the UPDATE are giving "404" so we ask that you copy the link and paste it in your browser. We are working to fix this issue.
Please report to us any questions or link issues.
A presentation for the American Association of Pharmaceutical Scientists (AAPS)
Regulatory Affairs and Biomarker Communities
" COVID-19 Variants: Science, Pharmacology and Challenges "
Is the Spike Protein Concentration generated by Vaccines dangerous? What about Infection?
The image below is a summary slide in the February Update showing the results of three studies on the amount of spike protein generated from an mRNA vaccine versus that generated from an active infection. The vaccines apparently make a circulating concentration that is below 100 pg/mL and for a few days. However, an infection can make 100X that amount at >10 ng/mL and persisting as long as the COVID virus remains actively reproducing. That is 100-fold more spike for a much longer period of time to have a causal effect.
The Moderna vaccine has shown a 6/100K vaccination-related myocarditis rate and Pfizer is only 1/100K. This may be population-related per the rationale that plasma degradation mechanisms may have a population bias.
The main issue regarding the vaccination levels is that myocarditis may not be due only to the presence of the spike in the heart (that is a given) but rather may be more related to ineffective circulating enzymes which degrade the spike. The clinical myocarditis outcomes may be different due to population differences. It may be beneficial to pre-screen individuals who have had myocarditis or are known to be depleted in needed enzymes for the degradation of circulating spike protein.
See the slide below for more details.
KEY POINTS ABOUT THE PANDEMIC TO RECOGNIZE
>> We are now over 1.1 Million US deaths since the start of the pandemic.
>> The Omicron progeny VOCs are now escalating with evidence of dispersion in city wastewater and cases are climbing (XBB, BQ.1.1. BF.7, and many more).
>> The Omicron VOCs appear to be affecting children more than adults, likely simply due to adult vaccinations and viral load transference in the young.
>> The COVID virus is going to continue to mutate and produce new variants and bivalent (two VOCs, original and BA.5) vaccines are now available
>> COVID-19 is a vascular disease with endothelial damage which pulmonary injury is included. Myocarditis and blood clotting pathologies are evident and carry risk. The vaccine spike is a significantly lower risk to the myocardium than infection.
>> Not unlike the flu vaccines and annual changes in the antigen identities used in the vaccines - COVID mutations are making changes in immune recognition and updated vaccines are going to be needed.
>> The vaccines provide a wide spectrum (2-log) of immune competence a few weeks after a vaccination and thence after a booster; but, 20% of the vaccinated do not render an adequate protection which leads to breakthrough infections and spreading.
>> Testing 2 times a week using ANTIGEN tests can provide a key metric on the infectious status of a subject. A POS test in a vaccinated person may be over 12 days (or longer) and one should expect that you are "infectious" to others. Quarantine and mask Antigen test to safely return to public settings.
>> An important issue is "Long COVID" which affects more than 20% of infected and new data is suggesting risks of diabetes, brain impairment, and cardiovascular injuries are showing long term (>12 mos) and one should avoid any COVID infection.
>>Natural (or, "herd") immunity (immunity by infection) does confer a wide array of antibodies (a fraction of the Abs are neutralizing) but it is dependent on the severity of infection and like the vaccinations, does not confer lasting immunity.
>> New vaccines for nasal delivery could prompt higher IgA serous antibodies to prevent nasal infection and reduce oral spreading, also, a T-cell assay that is rapid and specific to identify the vulnerable who cannot retain immunity or are refractory to vaccines (T-cells retain memory to train B-cell antibody production) would be useful)
>> We are now over 1.1 Million US deaths since the start of the pandemic.
>> The Omicron progeny VOCs are now escalating with evidence of dispersion in city wastewater and cases are climbing (XBB, BQ.1.1. BF.7, and many more).
>> The Omicron VOCs appear to be affecting children more than adults, likely simply due to adult vaccinations and viral load transference in the young.
>> The COVID virus is going to continue to mutate and produce new variants and bivalent (two VOCs, original and BA.5) vaccines are now available
>> COVID-19 is a vascular disease with endothelial damage which pulmonary injury is included. Myocarditis and blood clotting pathologies are evident and carry risk. The vaccine spike is a significantly lower risk to the myocardium than infection.
>> Not unlike the flu vaccines and annual changes in the antigen identities used in the vaccines - COVID mutations are making changes in immune recognition and updated vaccines are going to be needed.
>> The vaccines provide a wide spectrum (2-log) of immune competence a few weeks after a vaccination and thence after a booster; but, 20% of the vaccinated do not render an adequate protection which leads to breakthrough infections and spreading.
>> Testing 2 times a week using ANTIGEN tests can provide a key metric on the infectious status of a subject. A POS test in a vaccinated person may be over 12 days (or longer) and one should expect that you are "infectious" to others. Quarantine and mask Antigen test to safely return to public settings.
>> An important issue is "Long COVID" which affects more than 20% of infected and new data is suggesting risks of diabetes, brain impairment, and cardiovascular injuries are showing long term (>12 mos) and one should avoid any COVID infection.
>>Natural (or, "herd") immunity (immunity by infection) does confer a wide array of antibodies (a fraction of the Abs are neutralizing) but it is dependent on the severity of infection and like the vaccinations, does not confer lasting immunity.
>> New vaccines for nasal delivery could prompt higher IgA serous antibodies to prevent nasal infection and reduce oral spreading, also, a T-cell assay that is rapid and specific to identify the vulnerable who cannot retain immunity or are refractory to vaccines (T-cells retain memory to train B-cell antibody production) would be useful)
Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
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Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
***************