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bmoyernh
This website page on the COVID-19 Pandemic is for educational purposes ONLY
All previous updates are now archived
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Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios, et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A.,
Satyamitra, Merriline M., Tadesse, Yeabsera S., et al.
Source: Radiation Research, 195(1) : 1-24
Published By: Radiation Research Society
bmoyernh
This website page on the COVID-19 Pandemic is for educational purposes ONLY
All previous updates are now archived
~~~~~~~~~~~~~~~
Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios, et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A., Satyamitra, Merriline M., Tadesse, Yeabsera S., et al. Source: Radiation Research, 195(1) : 1-24 Published By: Radiation Research Society
Our most recent COVID-19 Update is now posted:
December 1, 2022 FINAL
There is new data everyday so we provide our next update as a draft.... stay up to date!
We have noticed some links in the UPDATE are giving "404" so we ask that you copy the link and paste it in your browser. We are working to fix this issue.
Please report to us any questions or link issues.
A presentation for the American Association of Pharmaceutical Scientists (AAPS)
Regulatory Affairs and Biomarker Communities
" COVID-19 Variants: Science, Pharmacology and Challenges "
Are Rapid Antigen Tests "failing" in detecting the Omicron variants?
No. The test is still able to find the N-protein, however, the presence of vaccine-induced adaptive immunity as well as T and B cell activation seen in convalescent plasma have changed the compartmental nature of the N protein abundance.
Infected cells are still mass producing the N-protein but the extracellular compartment is now decreasing the N protein abundance yielding LESS protein in the nose and throat swabs. The Antigen Tests are sensitive to a PCR Ct score of 30 in the naive patient but in a previously vaccinated or previously infected, the abundance is more likely representing a Ct score of ~33 and that is a NEG RAT outcome (insufficient to change the color) even while the subject is symptomatic..
The figure below describes the compartmental changes that have come from adaptive interventions..
KEY POINTS ABOUT THE PANDEMIC TO RECOGNIZE
>> We are now over 1.1 Million US deaths since the start of the pandemic.
>> The Omicron progeny VOCs are now escalating with evidence of dispersion in city wastewater and cases are climbing (XBB, BQ.1.1. BF.7, and many more).
>> The Omicron VOCs appear to be affecting children more than adults, likely simply due to adult vaccinations and viral load transference in the young.
>> The COVID virus is going to continue to mutate and produce new variants and bivalent (two VOCs, original and BA.5) vaccines are now available
>> COVID-19 is a vascular disease with endothelial damage which pulmonary injury is included. Myocarditis and blood clotting pathologies are evident and carry risk. The vaccine spike is a significantly lower risk to the myocardium than infection.
>> Not unlike the flu vaccines and annual changes in the antigen identities used in the vaccines - COVID mutations are making changes in immune recognition and updated vaccines are going to be needed.
>> The vaccines provide a wide spectrum (2-log) of immune competence a few weeks after a vaccination and thence after a booster; but, 20% of the vaccinated do not render an adequate protection which leads to breakthrough infections and spreading.
>> Testing 2 times a week using ANTIGEN tests can provide a key metric on the infectious status of a subject. A POS test in a vaccinated person may be over 12 days (or longer) and one should expect that you are "infectious" to others. Quarantine and mask Antigen test to safely return to public settings.
>> An important issue is "Long COVID" which affects more than 20% of infected and new data is suggesting risks of diabetes, brain impairment, and cardiovascular injuries are showing long term (>12 mos) and one should avoid any COVID infection.
>>Natural (or, "herd") immunity (immunity by infection) does confer a wide array of antibodies (a fraction of the Abs are neutralizing) but it is dependent on the severity of infection and like the vaccinations, does not confer lasting immunity.
>> New vaccines for nasal delivery could prompt higher IgA serous antibodies to prevent nasal infection and reduce oral spreading, also, a T-cell assay that is rapid and specific to identify the vulnerable who cannot retain immunity or are refractory to vaccines (T-cells retain memory to train B-cell antibody production) would be useful)
>> We are now over 1.1 Million US deaths since the start of the pandemic.
>> The Omicron progeny VOCs are now escalating with evidence of dispersion in city wastewater and cases are climbing (XBB, BQ.1.1. BF.7, and many more).
>> The Omicron VOCs appear to be affecting children more than adults, likely simply due to adult vaccinations and viral load transference in the young.
>> The COVID virus is going to continue to mutate and produce new variants and bivalent (two VOCs, original and BA.5) vaccines are now available
>> COVID-19 is a vascular disease with endothelial damage which pulmonary injury is included. Myocarditis and blood clotting pathologies are evident and carry risk. The vaccine spike is a significantly lower risk to the myocardium than infection.
>> Not unlike the flu vaccines and annual changes in the antigen identities used in the vaccines - COVID mutations are making changes in immune recognition and updated vaccines are going to be needed.
>> The vaccines provide a wide spectrum (2-log) of immune competence a few weeks after a vaccination and thence after a booster; but, 20% of the vaccinated do not render an adequate protection which leads to breakthrough infections and spreading.
>> Testing 2 times a week using ANTIGEN tests can provide a key metric on the infectious status of a subject. A POS test in a vaccinated person may be over 12 days (or longer) and one should expect that you are "infectious" to others. Quarantine and mask Antigen test to safely return to public settings.
>> An important issue is "Long COVID" which affects more than 20% of infected and new data is suggesting risks of diabetes, brain impairment, and cardiovascular injuries are showing long term (>12 mos) and one should avoid any COVID infection.
>>Natural (or, "herd") immunity (immunity by infection) does confer a wide array of antibodies (a fraction of the Abs are neutralizing) but it is dependent on the severity of infection and like the vaccinations, does not confer lasting immunity.
>> New vaccines for nasal delivery could prompt higher IgA serous antibodies to prevent nasal infection and reduce oral spreading, also, a T-cell assay that is rapid and specific to identify the vulnerable who cannot retain immunity or are refractory to vaccines (T-cells retain memory to train B-cell antibody production) would be useful)
Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
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Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
***************