COVID-19 Pandemic Presentations:
> February 2020
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> April 2020
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> June 2020
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> August 2020
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> School Openings (updated Mar 2021)
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>October 2020
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November 2020
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December 2020
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February 2021
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April 2021
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Supplement on Vitamin D and COVID-19
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Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A.,
Satyamitra, Merriline M., Tadesse, Yeabsera S., et al.
Source: Radiation Research, 195(1) : 1-24
Published By: Radiation Research Society
Supplement No. 4:
The Utility of Ivermectin - a way to abate the asymptomatic period?
Supplement No, 5:
PCR and Ct Scores Explained!
> February 2020
> April 2020
> June 2020
> August 2020
> School Openings (updated Mar 2021)
>October 2020
November 2020
December 2020
February 2021
April 2021
~~~~~~~~~~~~~~~
Supplement on Vitamin D and COVID-19
~~~~~~~~~~~~~~~
Radiation Injury Similarities
Click HERE
Also, A recent Radiation Research Journal Article on COVID and Radiation Injury, Rios et al. here:
Commonalities Between COVID-19 and Radiation Injury, Authors: Rios, Carmen I., Cassatt, David R., Hollingsworth, Brynn A., Satyamitra, Merriline M., Tadesse, Yeabsera S., et al. Source: Radiation Research, 195(1) : 1-24 Published By: Radiation Research Society
Supplement No. 4:
The Utility of Ivermectin - a way to abate the asymptomatic period?
Supplement No, 5:
PCR and Ct Scores Explained!
NEWS BRIEF OF THE DAY (11/14/2020):
SARS-CoV-2 mRNA vaccine technologies
There are four main safety and efficacy advantages of the use
of mRNA-based antiviral vaccines over traditional approaches.
First, mRNA-based antiviral vaccines minimize the potential risk
of infection and insertion-induced mutagenesis due to natural
degradation of mRNA in the cellular microenvironment.
Second, the immunogen’s high efficacy due to engineered mRNA
structural modifications improves its stability and translation
efficacy. Third, the high potency of mRNA-based vaccines capable of generating potent antiviral neutralizing immunoglobulins with only one or two low-dose immunizations may induce strong immune responses by activating both CD8+
and CD4+ T cells. Fourth, engineered mRNA production
facilitates large-scale production of sufficient vaccine doses
required to treat mass populations. All these factors
make the mRNA vaccine more suitable for a rapid response
to the emerging COVID-19 pandemic.
(click to enlarge the figure)
NEW TOPIC of CONTROVERSY:
"Herd Immunity" by rampant infection? - Is it a possibility? NO.
Why? No infectious agent has ever done so on its own. The premise is a thought experiment where people of low risk get infected and resolve the infection without harm and that it would have to be about 65% of the US population placed at risk of infection sequelae (aka the "long haulers").
Herd immunity might be possible for COVID-19 by immunization. However, the antibody response wanes in a few months and advocates suggest T-cell memory will reinstate B-cell antibodies upon a reinfection. The problem is clonal replenishment of Abs takes weeks, coupled with the known damping of INF by COVID-19, provides for sustained viral injury and future health staus is likely compromised.with each new re-infection.
If we allow rampant infection with a 2.75% death rate (current Oct) then 210M (65% of 328M population) will yield 5.7M deaths.
(lick to enlarge figure)
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Our New June Bimonthly Update (No. 10 in the Series) is available here:
CLICK HERE
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The full text of the American Rescue Plan signed by President Biden
Have a look and see how your Tax Dollars are going to be used
Our New June Bimonthly Update (No. 10 in the Series) is available here:
CLICK HERE
~~~~~~~~
The full text of the American Rescue Plan signed by President Biden
Have a look and see how your Tax Dollars are going to be used
Is there a problem if you get your second dose of vaccine AFTER 3-4 weeks? Maybe not.
Modeling studies have shown the vaccine may actually get a better neutralizing titer (>1:320) if administered even out 2 to 3 months.
Astra Zeneca (Feb 1), in a LANCET pre-print, has now published results of delay from 4 weeks to 12 weeks and shows an increase in neutralizing Abs with delay.
See the mathematical model paper supporting more time: CLICK HERE
What does the PCR signal really mean? What does it mean to be "Infectious" versus "Infected"? "Symptomatic" versus "Asymptomatic"? This graphic may help.
Here is a plot that may shed light on what it means to be PCR POS and what that means in terms antigen test results and what about time and proximity to an unmasked infected person? The dynamics of the viral contagiousness is PCR Ct-score dependent.
The UK variant (B.1.1.7) has now appeared in 49 states and Puerto Rico and the South African (SA; B.1.357) and Brazilian (P.1.) variants are also spreading in the US.
A new variant in southern CA is emerging off the SA origin clade 20C as CAL.20C with the mutation L452R - as of Feb 1st it the majority of POS samples in CA.
See the new Supplement on the Vaiants below and our April Bimonthly Update
What have we learned about COVID-19 in 2020? (updated Jan 31, 2021):
15 Lessons on COVID-19
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Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
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New targeted topic Supplement Presentations:
Supplement No. 1 (revised 3/19/21): Vitamin D and COVID-19
A major revision dated March 19th is now available. We cover the mechaistic actions of Vitamin D and its receptor on reducing cytokine stresses. We also cover the racial diaparities in Blacks, Hispanics and Whites in Vit D blood levels and COVID risk.
Supplement No. 2: The UK, South African, Brazilian and now So CA Variants and Risk (updated 3/15/2021)
Information on the new variants in the UK, South Africa, Brazil and the US including the new So California variant and issues about variants and infectivity
Supplement No. 3: Radiation Injury and COVID-19 Injury
Radiation is a generator of reactive oxygen - so is COVID-19
Supplement No. 4. Ivermectin-Summary (updated 3/5/21)
Ivermectin as a therapeutic for COVID-19 ~ can an antihelmenthic drug (antiparasite) help reduce disease symptoms?
Supplement No. 5. PCR Explained and When To Use Ag Testing
PCR is very sensitive and may not be the best way to sort out infectious subjects. Antigen tests are sensitive BELOW a PCR cycle count (Ct) of 30 identifying those subjects who are shedding/spreading the virus.
A NEW update on the Utility of Antigen Testing to Control the Epidemic is now available (April 2021)
Supplement No 6. What About School Openings (updated 3/6/21)
New slides on classroom CO2 (expired air) used as a surrogate "viral load"
An in-depth assessment of the childhood biology of COVID infection risks, school mitigation processes, and more.
This has the NEW CDC Guidelines from Feb 12, 2021 included and with links.
Can we have safe school openings? YES.
NEW!!
Supplement No. 7. COVID-19 and Vascular Endothelial Damage
This new Supplement covers the COVID's actions on the vascular endothelium, NF-KB signaling, NOTCH signaling, Radiation/ROS injury similarities, and more.
Supplement No. 8. FLUVOXAMINE - An antidepressant for COVID-19?
(added 3/10/2021)
Yes, Fluvoxamine is a serotonin reuptake inhibitor (SSRI) drug for depression but it also has a high binding to the sigma-1 receptor and that conveys anti-inflammation properties
It may be useful in treating early symptom patients to reduce hospitalizations
A new variant in southern CA is emerging off the SA origin clade 20C as CAL.20C with the mutation L452R - as of Feb 1st it the majority of POS samples in CA.
See the new Supplement on the Vaiants below and our April Bimonthly Update
What have we learned about COVID-19 in 2020? (updated Jan 31, 2021):
15 Lessons on COVID-19
~~~~~~~~~
Is your state, or where your friends/relatives live, doing enough testing?
Check this site (This site is updated daily) Click this LINK
***************
New targeted topic Supplement Presentations:
Supplement No. 1 (revised 3/19/21): Vitamin D and COVID-19
A major revision dated March 19th is now available. We cover the mechaistic actions of Vitamin D and its receptor on reducing cytokine stresses. We also cover the racial diaparities in Blacks, Hispanics and Whites in Vit D blood levels and COVID risk.
Supplement No. 2: The UK, South African, Brazilian and now So CA Variants and Risk (updated 3/15/2021)
Information on the new variants in the UK, South Africa, Brazil and the US including the new So California variant and issues about variants and infectivity
Supplement No. 3: Radiation Injury and COVID-19 Injury
Radiation is a generator of reactive oxygen - so is COVID-19
Supplement No. 4. Ivermectin-Summary (updated 3/5/21)
Ivermectin as a therapeutic for COVID-19 ~ can an antihelmenthic drug (antiparasite) help reduce disease symptoms?
Supplement No. 5. PCR Explained and When To Use Ag Testing
PCR is very sensitive and may not be the best way to sort out infectious subjects. Antigen tests are sensitive BELOW a PCR cycle count (Ct) of 30 identifying those subjects who are shedding/spreading the virus.
A NEW update on the Utility of Antigen Testing to Control the Epidemic is now available (April 2021)
Supplement No 6. What About School Openings (updated 3/6/21)
New slides on classroom CO2 (expired air) used as a surrogate "viral load"
An in-depth assessment of the childhood biology of COVID infection risks, school mitigation processes, and more.
This has the NEW CDC Guidelines from Feb 12, 2021 included and with links.
Can we have safe school openings? YES.
NEW!!
Supplement No. 7. COVID-19 and Vascular Endothelial Damage
This new Supplement covers the COVID's actions on the vascular endothelium, NF-KB signaling, NOTCH signaling, Radiation/ROS injury similarities, and more.
Supplement No. 8. FLUVOXAMINE - An antidepressant for COVID-19?
(added 3/10/2021)
Yes, Fluvoxamine is a serotonin reuptake inhibitor (SSRI) drug for depression but it also has a high binding to the sigma-1 receptor and that conveys anti-inflammation properties
It may be useful in treating early symptom patients to reduce hospitalizations
The COVID Varients: The change in PCR:
Click here for the link to the image:
https://www.slideshare.net/sabcnews/the-2nd-covid19-wave-in-south-africa-transmissibility-a-501v2-variant; slide 10 is displayed.
The Ct score is the PCR "cycle number" or, the number of amplification cycles needed to obtain a statistically "real" signal (viral copy number).
The South African variant N501Y) has a lower (more infectious) Ct score versus three previous variants.
Our COVID-19 Bimonthly Update Presentations
We have delved deep into the science behind this pandemic and the public needs help in understanding the terminology, the tests, the risks and how to navigate these troubled times. We hope these slide decks will help you.
We have delved deep into the science behind this pandemic and the public needs help in understanding the terminology, the tests, the risks and how to navigate these troubled times. We hope these slide decks will help you.
Bimonthly Updates: February 2020 through June 2021
